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Oral and Gut Microbiota Changes During Long-term Fasting in Humans

NCT05449249 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2023-01-13

No results posted yet for this study

Summary

The aim of this longitudinal trial is to investigate the effects of a 10±3-day fasting period in 30 subjects. Changes in the oral and gut microbiota, halitosis, as well as inflammatory and antioxidative parameters and biomarkers of sulfur metabolism will be analysed.

Conditions

  • Healthy
  • Periodontitis

Interventions

PROCEDURE

Long-term fasting

The participants will undergo a fasting program that includes the daily intake of 250 kcal under medical supervision.

Sponsors & Collaborators

  • Buchinger Wilhelmi Clinic

    collaborator UNKNOWN

  • University of Geneva, Switzerland

    collaborator OTHER

  • King's College London

    collaborator OTHER

  • ETH Zurich (Switzerland)

    collaborator OTHER

  • Buchinger Wilhelmi Development & Holding GmbH

    lead OTHER

Principal Investigators

  • Françoise Wilhelmi de Toledo, MD · Buchinger Wilhelmi

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-01
Primary Completion
2022-10-08
Completion
2023-01-06

Countries

  • Germany

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05449249 on ClinicalTrials.gov