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Metagenome Resilience in Experimental Gingivitis

NCT05389124 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2023-01-30

No results posted yet for this study

Summary

This study aims to identify new biomarkers that indicate the resilience of individuals to developing oral disease. An 'experimental gingivitis' model will be employed in which subjects will refrain from oral hygiene in one quadrant of their mouths for 3 weeks, and will then restore oral hygiene. Gum inflammation will be monitored by clinical measures throughout the trial and samples will be collected for analysis of microbial DNA and RNA.

Conditions

  • Gingivitis
  • Oral Disease

Interventions

BEHAVIORAL

Partial abstinence from oral hygiene

One quadrant of the dentition will be protected from oral hygiene for 3 weeks.

Sponsors & Collaborators

  • Unilever SEAC

    collaborator INDUSTRY

  • Newcastle-upon-Tyne Hospitals NHS Trust

    collaborator OTHER

  • Newcastle University

    lead OTHER

Principal Investigators

  • Nicholas S Jakubovics, PhD · Newcastle University

  • Richard Holliday, PhD · Newcastle University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-05-23
Primary Completion
2022-12-09
Completion
2022-12-09

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05389124 on ClinicalTrials.gov