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Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)

NCT05190432 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2026-05-13

No results posted yet for this study

Summary

The complexities of the immune system make measuring the impact of dietary interventions upon its function challenging. The immune system is highly responsive to environmental influences, including the diet. An individual's diet provides the energy required to mount a strong and protective immune response, the building blocks required for synthesis of immune mediators such as antibodies and cytokines, and can also indirectly affect immune function via changes in the gut microbiome. Immune function varies across the lifecourse, with a well understood decline in immune function with age, resulting in impaired vaccination responses and an increased risk of infections and of severe complications and mortality arising from common communicable diseases such as influenza. This impaired immunity with ageing is known as immunosenescence and this affects both innate and acquired arms of the immune system.

Conditions

Interventions

DIETARY_SUPPLEMENT

Taxifolin

A naturally occurring polyphenol found in apples, onions and other fruits and bark extracts.

DIETARY_SUPPLEMENT

Ergothioneine

An amino acid found in mushrooms, oats and some bean varieties.

DIETARY_SUPPLEMENT

Control

Microcrystalline cellulose.

Sponsors & Collaborators

  • Blue California

    collaborator INDUSTRY

  • University of Southampton

    lead OTHER

Principal Investigators

  • Caroline E Childs, PhD · University of Southampton

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-11-10
Primary Completion
2022-09-29
Completion
2026-07-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05190432 on ClinicalTrials.gov