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Bioavailability of Proteins From Plant Based Diets

NCT04866927 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 5

Last updated 2021-04-30

No results posted yet for this study

Summary

Proteins play an important role as structural and functional components for the human body and prevent stunting. Protein quality has a great importance in meeting the nutritional needs of populations across the world throughout the life course, particularly during pregnancy and early childhood. Dietary protein deficiency is mainly due to protein indigestibility limiting indispensable amino acids (IAAs) bioavailability. In Morocco, as it's the case in many developing countries, diet is mainly based on a large consumption of cereals, fruits, vegetables and pulses, and is generally low in meat, which is the main source of protein and IAA.

The general objective of this study is to evaluate the digestibility of Fava bean proteins and bioavailability of IAA using a dual-tracer method with stable isotopes.

Conditions

  • Protein Malabsorption
  • Nutritional Deficiency
  • Nutritional Stunting

Interventions

DIETARY_SUPPLEMENT

Use of stable isotopic dilution to assess protein digestibility from Faba bean and to evaluate amino acid bioavailability

Each participant will receive a test meal containing 13C labelled spirulina, 2H labelled Fava bean and 13C phenylalanine. The test meal will be divided on 11 subdoses: 3 sub-doses will be administrated at T0 and 1 subdose will be administrated at 1, 2, 3, 4, 5, 6 and 7h. The remaining sub-dose will be kept for measurement of IAA in the test meal. After eating the test meal, blood, urine and breath samples will be collected from each participant at the baseline (T0) and after 5-6, 7h and 8h.

Sponsors & Collaborators

  • AgroParisTech

    collaborator OTHER

  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

    collaborator OTHER

  • Centre National De L'énergie, Des Sciences Et Techniques Nucléaires

    collaborator OTHER_GOV

  • International Atomic Energy Agency

    lead OTHER_GOV

Principal Investigators

  • Mohammed El Mzibri · Head of the Division of Life Sciences - CNESTEN

  • Hassan Aguenaou · Director of Nutrition RDC of Morocco

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-11-25
Primary Completion
2019-12-31
Completion
2020-02-15

Countries

  • Morocco

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04866927 on ClinicalTrials.gov