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Serum Pro-Diabetes Inflammation Biomarkers in Patients With Apical Periodontitis.

NCT04824209 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 27

Last updated 2023-04-28

No results posted yet for this study

Summary

Inflammation is a common factor of chronic periodontitis and diabetes. However, to date, there is no scientific evidence supporting a causal effect of the inflammation created by apical periodontitis on the onset of insulin resistance and on metabolic derangement in the condition of pre-diabetes or diabetes.

A case control study has been designed in order to evaluate serum levels of pro-diabetes inflammation factors in a sample of healthy patients between 25 and 55 years of age, with or without apical periodontitis,before endodontic treatment and at 6 and 12 months post-treatment. The aim of the study is to evaluate any relation between the presence of chronic endodontic lesions and pro-diabetes inflammation factors that can promote the onset of insulin resistance, and whether endodontic treatment can reduce these factors, thus preventing a pro-diabetes status.

Conditions

Sponsors & Collaborators

  • University of Turin, Italy

    lead OTHER

Principal Investigators

  • Damiano Pasqualini, DDS Ass Pro · Endodontics, Department of Surgical Sciences - Univeristy of Turin

Eligibility

Min Age
25 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-02-09
Primary Completion
2022-04-30
Completion
2023-04-25

Countries

  • Italy

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04824209 on ClinicalTrials.gov