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Healing of Apical periodontitis-the Effect of Diabetes Mellitus and Tobacco Smoking

NCT04812171 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2023-07-05

No results posted yet for this study

Summary

Apical periodontitis is an inflammatory process located around the apex of the root. It is mainly caused by a microbial infection of the pulp space. Diabetes mellitus and tobacco smoking are modulating factors that may influence the healing of apical periodontitis. Present studies have disclosed an association between smoking and apical periodontitis and diabetes mellitus and apical periodontitis. The aim of this study is to compare the healing of periapical bone in smokers and non-smokers and patients with diabetes mellitus type 2 and healthy participants. The hypothesis of this study is that smokers and patients diagnosed with diabetes mellitus will experience slower healing with a lower success rate in comparison to control groups. Apical periodontitis will be diagnosed through means of clinical examination and radiological analysis. Healing of apical periodontitis will be determined using periapical radiographs utilizing periapical index. This prospective study will contribute to the development of clinical guidelines concerning smokers and patients with diabetes mellitus type 2.

Conditions

  • Periapical Periodontitis

Interventions

PROCEDURE

non-surgical endodontic treatment

standard non-surgical endodontic treatment performed by endodontic specialist

Sponsors & Collaborators

  • University of Rijeka

    collaborator OTHER

  • Romana Peršić Bukmir

    lead OTHER

Principal Investigators

  • Sonja Pezelj-Ribarić, PhD,DMD · Faculty of Dental Medicine, University of Rijeka, Croatia

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-01
Primary Completion
2023-07-03
Completion
2023-07-03

Countries

  • Croatia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04812171 on ClinicalTrials.gov