Orange Juice, Hesperidin and Their Role in Vascular Health Benefit

Summary

Although epidemiological studies have associated the consumption of sugary beverages with adverse health effects, experimental studies have demonstrated that the metabolic response of the human body to fruit juice as compared to artificial beverages is substantially different. Fruit juices do not just provide sugars and related calories, but they are rich sources of bioactive compounds especially of flavonoids. Flavanones constitute a class of flavonoids that are specifically and abundantly found in citrus fruits, with hesperidin being the major compound in orange. From prospective cohort studies, higher intakes of flavanones are associated with a lower incidence of mortality by cardiovascular disease (CVD). This relation is supported by results from a number of animal studies demonstrating a slowdown in atherosclerosis development and vascular protective effects in dietary interventions with flavanones. Randomized, controlled clinical trials to corroborate the suggested vasculo-protective effects of orange juice presumably mediated by the flavanones are scarce and available data do not allow to draw firm conclusions about their efficacy. To fill this gap, the "HESPER-HEALTH study" conducted in humans will assess the vascular protective effects of 100% orange juice consumption and evaluate the contribution of hesperidin in these effects.

Conditions

• Metabolic Syndrome
• Vascular Compliance
• Predisposition to Cardiovascular Disease

Interventions

BEHAVIORAL

Beverage consumption

Volunteers will consume, in random order, daily 330 ml of 1 experimental beverage per period (Orange Juice, Control Beverage, Control Beverage supplemented with hesperidin) for 6 weeks in each period. At the beginning and the end of each period, exploration will be conducted at fasted state and at post-prandial state after the administration of a high-fat high-sugar meal.

Sponsors & Collaborators

• UMR 1019, Unité de Nutrition Humaine, INRAE, Auvergne-Rhône Alpes Center

  collaborator UNKNOWN

• Department of Beverage Research, Chair of analysis and technology of plant-based foods, Geisenheim University

  collaborator UNKNOWN

• European Fruit Juice Association (AIJN)

  collaborator UNKNOWN

• University Hospital, Clermont-Ferrand

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Model

CROSSOVER

Eligibility

Min Age

40 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-02-24

Primary Completion

2023-06-20

Completion

2023-06-20

Countries

• France

Study Locations