Lung Structure-Function In Survivors of Mild and Severe COVID-19 Infection

Summary

This is a longitudinal study of the long-term impact of COVID-19 on the lungs. Participants will be followed over a period of up to 4 years and impacts of COVID-19 on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129, pulmonary function tests, exercise capacity, computed tomography imaging and questionnaires.

Conditions

• Covid19

Interventions

DIAGNOSTIC_TEST

Hyperpolarized Xenon-129 MRI of the lungs

Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas

DIAGNOSTIC_TEST

Computed Tomography (CT)

Participants will undergo a CT scan of the thoracic cavity

DIAGNOSTIC_TEST

Pulmonary Function Tests (PFT)

Participants will have their lung function evaluated using PFT

DIAGNOSTIC_TEST

Six Minute Walk Test (6MWT)

Participants will perform the six minute walk test as a measure of exercise capacity

DIAGNOSTIC_TEST

Sputum analysis

Participants will provide a sputum sample that will be analysed for eosinophils

DIAGNOSTIC_TEST

Blood analysis

Participants will have their blood drawn and analysed for eosinophil count.

OTHER

Questionnaires

Participants will complete questionnaires to assess activity related dyspnea, respiratory symptoms and health status impairment and respiratory related quality of life.

Sponsors & Collaborators

• London Health Sciences Centre

  collaborator OTHER

• Western University, Canada

  lead OTHER

Principal Investigators

• Grace E Parraga, PhD · Robarts Research Institute, The University of Western Ontario

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-01-01

Primary Completion

2026-09-01

Completion

2026-12-01

Countries

• Canada

Study Locations