Lung Function, Exercise Capacity, and Serology Responses in Patients With COVID-19

Summary

(a) Objectives

1. To assess the full lung function, exercise capacity, quality of life in patients with COVID-19 over 2 years.
2. To assess the longevity of the serology response to SARS-CoV2.
3. To investigate the association of the neutralization titer in plasma from different vaccinated cohorts to its protection of infection using in vivo model
4. To investigate the SARS-CoV-2 specific cellular and humoral immunities as well as their determinant factors from community subjects who have received different types of COVID-19 vaccines.
5. To assess the third booster dose for subjects who have poor antibody response despite having received two doses of CoronaVac (Sinovac)

Conditions

• Lung Function
• Exercise Capacity
• Quality of Life
• Covid19

Interventions

BIOLOGICAL

third dose vaccination with CoronaVac vaccine

Healthy individuals with low antibody levels after 2 doses of CoronaVac vaccine to receive one additional dose of CoronaVac vaccine

BIOLOGICAL

third dose vaccination with BionTech vaccine

Healthy individuals with low antibody levels after 2 doses of CoronaVac vaccine to receive one additional dose of BionTech vaccine

BIOLOGICAL

Vaccination with Coronavac vaccine

Healthy individuals to receive Coronavac vaccine 2 doses, 21 days apart

BIOLOGICAL

Vaccination with BionTech Vaccine

Healthy individuals to receive BionTech vaccine 2 doses, 21 days apart

Sponsors & Collaborators

• The University of Hong Kong

  collaborator OTHER

• Health and Medical Research Fund

  collaborator OTHER_GOV

• Chinese University of Hong Kong

  lead OTHER

Principal Investigators

• David S Hui, MD · Chinese University of Hong Kong

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-05-22

Primary Completion

2025-08-18

Completion

2026-02-17

Countries

• Hong Kong

Study Locations