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Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking

NCT03909477 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2025-08-15

No results posted yet for this study

Summary

This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.

Conditions

  • Cannabis Use
  • Cannabis Smoking
  • Marijuana Smoking
  • Marijuana Usage

Interventions

DIAGNOSTIC_TEST

Hyperpolarized Xenon-129 MRI of the lungs

Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas

DIAGNOSTIC_TEST

Computed Tomography (CT)

Participants will undergo a CT scan of the thoracic cavity

DIAGNOSTIC_TEST

Pulmonary Function Tests (PFTs)

Participants will have their lung function evaluated using PFTs

DIAGNOSTIC_TEST

Six Minute Walk Test (6MWT)

Participants \>35 years of age will perform the six minute walk test as a measure of exercise capacity

DIAGNOSTIC_TEST

Cardiopulmonary exercise testing (CPET)

Participants \<35 will perform cardiopulmonary exercise testing as a measure of exercise capacity

DIAGNOSTIC_TEST

Sputum analysis

Participants will provide a sputum sample that will be analysed for eosinophils

DIAGNOSTIC_TEST

Blood analysis

Participants will have their blood drawn and analysed for eosinophil count.

Sponsors & Collaborators

  • Western University, Canada

    lead OTHER

Principal Investigators

  • Grace E Parraga, PhD · Robarts Research Institute, The University of Western Ontario

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-06-01
Primary Completion
2030-12-01
Completion
2030-12-01

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03909477 on ClinicalTrials.gov