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Healthy Lung Study- Development of 3T MRI Hardware and Software for 3He Gas Imaging of the Lung: Healthy Volunteer Development Study

NCT03169673 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 66

Last updated 2025-08-11

No results posted yet for this study

Summary

Healthy volunteers aged 18-75 will undergo hyperpolarized 3-Helium MRI and pulmonary function testing for the development of tools to assess image signal to noise and reproducibility of spin-density and diffusion-weighted imaging.

Conditions

  • Healthy Volunteers

Interventions

DIAGNOSTIC_TEST

Hyperpolarized Helium 3 Magnetic Resonance Imaging

Hyperpolarized noble gas imaging using Helium-3 has been used to explore structural and functional relationships in the lung in patients with lung disease and healthy controls. In contrast to proton-based MRI imaging, 3He gas is used as a contrast agent to directly visualize the airways, and thus ventilation. Whereas the normal density of gas is too low to produce an easily detectable signal, this is overcome by artificially increasing the amount of polarization per unit volume using optical pumping.

Sponsors & Collaborators

  • London Health Sciences Centre

    collaborator OTHER

  • Western University, Canada

    lead OTHER

Principal Investigators

  • Grace E Parraga, PhD · Study Principal Investigator Robarts Research Institute, The University of Western Ontario

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-09-21
Primary Completion
2025-01-31
Completion
2025-01-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03169673 on ClinicalTrials.gov