Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders

Summary

The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used. This study will take place at TBRHSC in the Cardiorespiratory Department and in the Research MRI facility.

Conditions

• Lung Transplant
• Lung Resection
• Lung Cancer
• Asthma
• Cystic Fibrosis
• Chronic Obstructive Pulmonary Disease
• Emphysema
• Mesothelioma
• Asbestosis
• Pulmonary Embolism
• Interstitial Lung Disease
• Pulmonary Fibrosis
• Bronchiectasis
• Seasonal Allergies
• Cold Virus
• Lung Infection
• Pulmonary Hypertension
• Pulmonary Dysplasia
• Obstructive Sleep Apnea

Interventions

DRUG

HP 3He

3He will be hyperpolarized using a custom-built polarizer to enhance its MRI signal. Hyperpolarization does not change the chemical or physical properties of helium gas.

DRUG

HP 129Xe

129Xe will be hyperpolarized using a Xemed polarizer to enhance its MRI signal. Hyperpolarization does not change the chemical or physical properties of xenon gas.

DRUG

PFP

Perfluoropropane (PFP) will be premixed and delivered to the participants with no further processing.

DRUG

SF6

Sulfur hexafluoride (SF6) will be premixed and delivered to the participant with no further processing.

DEVICE

129Xe Small and Large Human Lung Coil

The investigational 129Xe small and large quadrature lung coils are sensitive to 129Xe resonant frequencies and therefore will be paired with the investigational drug 129Xe. The size of the coil used will depend on the participants' body size.

DEVICE

3He Human Lung Coil

The investigational 3He quadrature lung coil is sensitive to 3He resonant frequencies and therefore will be paired with the investigational drug 3He.

DEVICE

PFP and SF6 Human Lung Coil

The investigational PFP and SF6 quadrature lung coil is sensitive to inert fluorinated gas resonant frequencies and therefore will be paired with both PFP and SF6.

Sponsors & Collaborators

• Thunder Bay Regional Health Sciences Centre

  collaborator OTHER

• St. Joseph's Care Group

  collaborator OTHER

• Lakehead University

  collaborator OTHER

• Thunder Bay Regional Health Research Institute

  lead OTHER

Principal Investigators

• Mitchell S Albert, PhD · Thunder Bay Regional Health Research Institute

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-11-10

Primary Completion

2021-10-16

Completion

2021-10-16

Countries

• Canada

Study Locations