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Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers

NCT04616313 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2025-08-14

No results posted yet for this study

Summary

This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.

Conditions

  • E Cigarette Use

Interventions

DIAGNOSTIC_TEST

Hyperpolarized Xenon-129 MRI of the lungs

Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas

DIAGNOSTIC_TEST

Computed Tomography (CT)

Participants will undergo a CT scan of the thoracic cavity

DIAGNOSTIC_TEST

Pulmonary Function Tests (PFT)

Participants will have their lung function evaluated using PFT

DIAGNOSTIC_TEST

Cardiopulmonary exercise testing (CPET)

Participants will perform cardiopulmonary exercise testing as a measure of exercise capacity

DIAGNOSTIC_TEST

Sputum analysis

Participants will provide a sputum sample that will be analysed for eosinophils

DIAGNOSTIC_TEST

Blood analysis

Participants will have their blood drawn and analysed for eosinophil count.

OTHER

Questionnaires

Participants will complete questionnaires to assess activity related dyspnea, respiratory symptoms and health status impairment and respiratory related quality of life.

Sponsors & Collaborators

  • London Health Sciences Centre

    collaborator OTHER

  • Western University, Canada

    lead OTHER

Principal Investigators

  • Grace E Parraga · Western University - Robarts Research Institute

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-17
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04616313 on ClinicalTrials.gov