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Respiratory Mechanics and Gas Exchange in Patients With COVID-19 and Hypoxemic Acute Respiratory Failure

NCT04445961 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 117

Last updated 2020-08-27

No results posted yet for this study

Summary

Data on respiratory mechanics and gas exchange in acute respiratory failure in COVID-19 patients is limited. Knowledge of respiratory mechanics and gas exchange in COVID-19 can lead to different selection of mechanical ventilation strategy, reduce ventilator-associated lung injury and improve outcomes. The objective of the study is to evaluate the respiratory mechanics, lung recruitability and gas exchange in COVID-19 -associated acute respiratory failure during the whole course of mechanical ventilation - invasive or non-invasive.

Conditions

  • SARS Pneumonia

Interventions

DIAGNOSTIC_TEST

Respiratory mechanics measurement

Measurement of peak inspiratory pressure, plateau pressure, calculation of static compliance and driving pressure

DIAGNOSTIC_TEST

Gas exchange measurement

Measurement of arterial oxygen and tension and arterial dioxide tension, calculation of arterial partial oxygen tension to inspiratory oxygen fraction (PaO2/FiO2) ratio and alveolar dead space

Sponsors & Collaborators

  • I.M. Sechenov First Moscow State Medical University

    lead OTHER

Principal Investigators

  • Andrey I Yaroshetskiy, Dr.Med.Sc. · Sechenov University

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-05-01
Primary Completion
2020-08-14
Completion
2020-08-14

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04445961 on ClinicalTrials.gov