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Description of Respiratory Mechanics in Patients With SARS-CoV-2 Associated ARDS

NCT04350710 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2020-04-17

No results posted yet for this study

Summary

The aim of this observationnal study is to describe respiratory mechanics and lung recruitement in patients with SARS-CoV-2 Associated Acute Respiratory Distress Syndrome who underwent invasive ventilation on endotracheal tube, admitted to the medical ICU of Angers university hospital . Statics measurements of respiratory system compliance were performed at 2 differents levels of PEEP (15 cmH2O and 5 cmH2O). The recruited volume is computed as the difference between the volume expired from PEEP 15 to 5 cmH2O and the volume predicted by compliance at PEEP 5 cmH2O . The recruitment-to-Inflation (R/I) ratio (i.e. the ratio between the recruited lung compliance and CRS at PEEP 5 cmH2O) is used to assess lung recruitability. A R/I ratio value higher than or equal to 0.5 was used to define highly recruiter patients.

Conditions

  • Acute Respiratory Distress Syndrome
  • COVID

Interventions

OTHER

PEEP trial

Measurement of Recruitment-to-Inflation Ratio

Sponsors & Collaborators

  • University Hospital, Angers

    lead OTHER_GOV

Principal Investigators

  • François BELONCLE, MCU PH · CHU Angers, Médecine intensive réanimation

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-03-18
Primary Completion
2020-04-20
Completion
2020-12-31

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04350710 on ClinicalTrials.gov