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Targeting Glutamine Metabolism to Prevent Diabetic Cardiovascular Complications

NCT04353869 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 995

Last updated 2025-03-05

No results posted yet for this study

Summary

Experimental data suggest that glutamine catabolism in involved in the activation of macrophages by generating TCA(Tricarboxylic acid) intermediates that promote the pro-inflammatory polarization of macrophages. The project investigates the possible link between glutaminolysis, monocytes polarization and diabetes related cardiovascular complications in humans

Conditions

Interventions

BIOLOGICAL

Bio collection

venous blood sampling and collection of urine

Sponsors & Collaborators

  • National Research Agency, France

    collaborator OTHER

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-16
Primary Completion
2024-01-10
Completion
2024-01-10

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04353869 on ClinicalTrials.gov