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Effects of Low and Moderate Fat Diets on Lipids, Inflammation and Vascular Reactivity in the Metabolic Syndrome

NCT00362908 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 71

Last updated 2010-10-28

No results posted yet for this study

Summary

The metabolic syndrome consists of five concurrent conditions which increase risk of heart disease, stroke, and diabetes. Persons with the metabolic syndrome usually have high triglyceride and low HDL levels and are overweight. Low fat, high carbohydrate diets may not provide the same cholesterol-lowering benefits to obese individuals as they do to non-obese individuals. The purpose of this study is to compare the effects of a low fat, high carbohydrate diet versus a moderate fat, moderate carbohydrate diet on the heart, blood vessels, and cholesterol levels in individuals with metabolic syndrome.

Conditions

  • Metabolic Syndrome X
  • Dyslipidemias

Interventions

BEHAVIORAL

Moderate Fat and Moderate Carbohydrate Diet

40% allowable fat diet (less than or equal to 7% saturated fat) consumed for 1 or 5 months

BEHAVIORAL

Low Fat and High Carbohydrate Diet

20% fat diet (less than or equal to 7% saturated fat) consumed for 1 or 5 months

Sponsors & Collaborators

Principal Investigators

  • Pathmaja Paramsothy, MD · University of Washington

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
30 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-09-30
Primary Completion
2009-09-30
Completion
2010-06-30

Countries

  • United States

Study Locations

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Entities

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00362908 on ClinicalTrials.gov