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The TCF7L2 Gene: Dietary Prevention of T2DM

NCT03458494 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 37

Last updated 2024-09-04

No results posted yet for this study

Summary

Nutrients and chemicals in food are able to regulate expression of genetic elements. Gene-nutrient interaction in response specific diets can increase an individual's risk, shifting the individual from health toward the development of chronic disease. The Transcription Factor 7 Like 2 (TCF7L2) gene may either put individuals at risk for or protect from Type 2 diabetes mellitus in the presence of certain foods. The main purpose of this four-week study is to examine diet-induced gene-nutrient interaction, with a focus on glucose, insulin, inflammation (CRP) and the plasma metabolome in individuals who have either the CC or the TT form of the rs7903146 single nucleotide polymorphism (SNP) (C/T) within the TCF7L2 gene. The (2) one-week study diets, one Mediterranean diet (MedDiet) based and the other low-fat based will be separated by a (1) week return to a regular habitual diet.

Conditions

  • Type2 Diabetes
  • Glucose, High Blood

Interventions

OTHER

Mediterranean Diet

Participants will receive meals traditionally consumed in Mediterranean countries

OTHER

Low-fat diet

Participants will receive meals with a low content of total fat.

Sponsors & Collaborators

  • Allen Foundation Inc.

    collaborator OTHER

  • Tufts University

    lead OTHER

Principal Investigators

  • Jose M Ordovas, PHD · Tufts University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-02-15
Primary Completion
2020-04-30
Completion
2020-04-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03458494 on ClinicalTrials.gov