Impact of Lifetime Exposure to Air and Noise Pollution on Cardiovascular Disease and Mortality - the AIRCARD Study.

Summary

The purpose of this study is to determine the impact of individually lifetime accumulated exposure to air and noise pollution on the incidence and prevalence of cardiovascular diseases (CVD) and mortality.

Air as well as noise pollution have harmful effects on human health. Experimental and clinical studies have shown a strong impact between particulate matter (PM2.5) and cardiovascular disease (CVD). Prolonged exposure to PM2.5 has been associated with the development of atherosclerosis and adverse cardiovascular events. However, also short-term exposure has been linked to acute coronary events. PM2.5 is, however, a combination of many components of specific pollutants that have a size of two and a half microns or less in width. However, there is a knowledge gap, as investigation into which specific components of air pollutants that contribute the most to the development of CVD is lacking. There is a need to adopt and encourage preventive measures but also put in place environmental policies that are effective in promoting the reduction of exposure to pollutants. We want to aid in this shift by showing which specific pollutants contribute the most to the development of CVD so that we can better target these specific air pollutants for better prevention initiatives.

Conditions

• Cardiovascular Diseases
• Particulate Matter Inhalation Injury
• Arteriosclerosis
• Pollution; Exposure

Sponsors & Collaborators

• DANCAVAS Study Group

  collaborator UNKNOWN

• Department of Environmental Science, Aarhus

  collaborator UNKNOWN

• Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital

  collaborator UNKNOWN

• Department of Cardiology, Odense University Hospital

  collaborator UNKNOWN

• Danish Cancer Society

  collaborator OTHER

• Odense University Hospital

  lead OTHER

Principal Investigators

• Stephan P Mayntz, MD, MPH · Odense University Hospital

• Jess Lambrechtsen, Prof., MD · Odense University Hospital

• Roda A Mohamed, MD · Odense University Hospital

Eligibility

Min Age

60 Years

Max Age

74 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-01-02

Primary Completion

2022-01-01

Completion

2026-09-01

Countries

• Denmark

Study Locations