Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus Surgery

Summary

Endoscopic Sinus surgery usually associated by bleeding, despite using of local vasopressor injection, head up position- controlled hypotension is generally used for control of this purpose.

Propofol has been reported as a good agent for controlled hypotension by decreasing systemic vascular resistance secondary to arterial and venous vasodilation and a decrease in myocardial contractility with a dose-dependent property.

Magnesium Sulfate also has been reported as an agent of hypotensive anaesthesia by inhibition of the release of norepinephrine by blocking N-type calcium channel at the nerve ending beside acting as a vasodilator.

The well known pharmacodynamic effects of the intravenous infusion of propofol or Magnesium Sulfate may prove the advantage of this group in controlling intraoperative blood pressure thus reducing surgical field bleeding.

Conditions

• Endoscopic Sinus Surgery

Interventions

DRUG

Propofol infusion

Following induction of anaesthesia, propofol infusion will be started 75 mcg/kg/min for the first 10-15 minutes, then a maintenance infusion of propofol (50 mcg/kg /min)

DRUG

Magnesium Sulfate infusion

Before induction of anaesthesia, Magnesium Sulfate infusion will be started at 40 mg/kg in 100 ml saline over 10 minutes as the loading dose then Magnesium sulfate infusion 10-15 mg/kg/hr started immediately after induction of anaesthesia

DRUG

Lidocaine

Patients will receive iv lidocaine 1.5 mg/kg before induction of anaesthesia

DRUG

Fentanyl

Patients will receive fentanyl 1-2 mcg/kg before induction of anaesthesia

DRUG

Propofol

Patients will receive propofol in a dose of 1-2 mg /kg

DRUG

Atracurium

Patients will receive 0.6 mg /kg iv atracurium over 60 sec, to facilitate tracheal intubation

PROCEDURE

Mechanical Ventilation

Patients lungs will be ventilated using the volume controlled mechanically ventilated with 40% oxygen in the air with positive end-expiratory pressure (PEEP) of 5 cmH2O, tidal volume 500 ml and Respiratory Rate of 12 per minute

Sponsors & Collaborators

• Mansoura University

  lead OTHER

Principal Investigators

• Hazem E Moawed · Assistant Professor of Anesthesia and Surgical Intensive Care

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

45 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-09-30

Primary Completion

2020-01-31

Completion

2020-02-29

Countries

• Egypt

Study Locations