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The Effect of Blood Pressure on Cerebral Blood Flow During Propofol Anesthesia

NCT03309917 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2018-07-26

No results posted yet for this study

Summary

General anesthesia often reduces blood pressure whereby blood flow to the brain and other vital organs may become insufficient. Thus, medicine is often administered to maintain blood pressure but it is unclear at what level blood pressure should be aimed at during anesthesia.

Thirty patients undergoing major abdominal surgery will be included. The study will start one hour after the start of surgery and lasts for approximately half an hour. The purpose of the study is to evaluate whether blood flow to the brain can be increased by maintaining blood pressure at a higher level than that used in clinical practice. In the study, MAP is adjusted to a high, moderate, and low level for a short time. The low level of blood pressure used in the study, corresponds to the level aimed at in clinical practice. The drug noradrenaline will be used to control blood pressure. Blood flow to the brain will be evaluated on the neck using ultrasound.

Conditions

  • Gastrointestinal Neoplasms
  • Anesthesia, General

Interventions

OTHER

MAP set at 80-85 mmHg for 5 min

MAP is set at 80-85 mmHg for 5 min by infusion of noradrenaline.

OTHER

MAP set at 70-75 mmHg for 5 min

MAP is set at 70-75 mmHg for 5 min by infusion of noradrenaline.

OTHER

MAP set at 60-65 mmHg for 5 min

MAP is set at 60-65 mmHg for 5 min by infusion of noradrenaline.

Sponsors & Collaborators

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Niels H Secher, MD, D.M.Sc. · Department of Anesthesia, Rigshospitalet 2043, DK-2100 Copenhagen Ø, Denmark

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-12-27
Primary Completion
2018-04-19
Completion
2018-04-19

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03309917 on ClinicalTrials.gov