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Comparison of Esketamine-Propofol and Fentanyl-Propofol

NCT05752409 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2023-08-15

No results posted yet for this study

Summary

Propofol is widely used as an induction agent during general anesthesia. The prevalent induction dose may be associated with unacceptable cardiovascular instability, especially in elderly patients.The combination of ketamine and propofol has been shown to balance the cardiodepressant effects. Esketamine is dextrorotatory structure of ketamine but with stronger analgesic effects and fewer adverse events.However, there have been no previous published reports on the use of esketamine combined with propofol during induction. The main aim of this study was to investigate the haemodynamic effects of esketamine with propofol for the elderly during induction with LMA( laryngeal mask airway) insertion.

Conditions

  • Hemodynamics

Interventions

DRUG

The median dose of esketamine

1mg•kg-1propofol and 0.5 mg•kg-1esketamine for general anesthesia induction.

DRUG

The high dose of esketamine

1mg•kg-1propofol and 0.75 mg•kg-1esketamine for general anesthesia induction.

DRUG

Propofol

2mg•kg-1propofol for general anesthesia induction.

Sponsors & Collaborators

  • Eye & ENT Hospital of Fudan University

    lead OTHER

Principal Investigators

  • Fang Tan · Anesthesiology Department of Affiliated Eye and ENT Hospital, Fudan University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-08
Primary Completion
2023-11-30
Completion
2023-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05752409 on ClinicalTrials.gov