MedTrace Logo

A Cross-sectional Study to Measure Cough in Severe Asthma

NCT03999203 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 61

Last updated 2023-11-22

Study results available
· View outcomes & findings →

Summary

This study aims to characterise cough in severe asthma through an observational cross-sectional analysis of patients stratified by inflammatory biomarker profile using a number of subjective and objective cough measurement tools.

Conditions

Interventions

DRUG

Citric acid

Citric Acid cough challenge to be administered to assess the cough reflex sensitivity in patients

DEVICE

Leicester Cough monitor

Ambulatory cough monitor to assess cough frequency over a 24 hour period

OTHER

fractional exhaled nitric oxide testing (FeNO)

Measurement of exhaled nitric oxide to give an indication of airway inflammation

OTHER

Patient reported outcome measures

A number a patient reported outcome measures will be administered including: Asthma control questionnaire (ACQ-5), mini Asthma Quality of Life Questionnaire (mini AQLQ), Leicester Cough Questionnaire (LCQ), Cough Quality of Life Questionnaire (CQLQ), Cough Hypersensitivity Questionnaire (CHQ) and visual analogue scales for severity og cough (VASc) and Urge to Cough (VASu)

Sponsors & Collaborators

Principal Investigators

  • Liam Heaney, MD · Queen's University, Belfast

  • Lorcan McGarvey, MD · Queen's University, Belfast

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-10-04
Primary Completion
2019-12-30
Completion
2019-12-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03999203 on ClinicalTrials.gov