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Novel Endpoints in Cough Challenge Testing

NCT01566968 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 98

Last updated 2012-04-06

No results posted yet for this study

Summary

The sensitivity of a person's cough reflex can be measured by getting them to breathe in (inhale) irritant chemicals. There are different methods by which subjects are asked to inhale these chemicals, either by taking one deep breath in, or by asking them to just continue to take a number of breaths. The purpose of this clinical research study is to see if the coughing responses are different in healthy people and people with respiratory problems that make them cough when they are given these chemicals in these two methods.

Conditions

Interventions

OTHER

Cough challenge test

Cough challenge will be performed with Capsaicin, citric acid and prostaglandin E2.

OTHER

24 hour ambulatory cough recording

Cough recording by using an ambulatory sound recording device.

OTHER

Cough quality of life questionnaire

questionnaire designed to assess impact of cough on a person's life

Sponsors & Collaborators

  • Manchester University NHS Foundation Trust

    lead OTHER_GOV

Principal Investigators

  • Saifudin Khalid, MRCP · University Hospital of South Manchester

  • Ashley Woodcock, MD · University Hospital of South Manchester

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-01-31
Primary Completion
2012-04-30
Completion
2012-04-30

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01566968 on ClinicalTrials.gov