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Prospective Study on the Evaluation, Patient Reported Outcomes and Effectiveness of Treatment for Chronic Cough

NCT04758351 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-05-06

No results posted yet for this study

Summary

Chronic cough is a common troublesome symptom which has a global prevalence of approximately 10%, but with wide variations across continents. The aim of this study is to evaluate the effectiveness of treatment, patient-reported outcomes and burden of disease in patients with chronic cough referred to a specialist clinic. The proposed study will use pre-defined diagnostic criteria, investigations and treatment algorithms such that all recruited patients will undergo the same investigations and follow a set management algorithm. This study will objectively and subjectively assess coughing at baseline and after treatment in a real-world clinical setting. This will allow us to understand the relationship between any objective reduction in cough after treatment, and whether this translates to any significant improvement in subjective questionnaire scores. We will assess the impact of health conditions on lost productivity in monetary units and assess the amount of absenteeism, presenteeism and daily activity impairment attributable to unexplained chronic cough/refractory chronic cough. Finally, a patient survey at the end of the study will evaluate the patients' satisfaction and experience of investigation, management trials and use of questionnaires.

Conditions

  • Chronic Cough

Interventions

OTHER

Usual clinical practice

Based on European Respiratory Society guidelines on management for chronic cough.

Sponsors & Collaborators

  • Merck Canada Inc.

    collaborator INDUSTRY

  • University of Manchester

    collaborator OTHER

  • University of British Columbia

    collaborator OTHER

  • McMaster University

    lead OTHER

Principal Investigators

  • Imran Satia, MD, PhD · McMaster University

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-12-14
Primary Completion
2025-04-30
Completion
2025-04-30

Countries

  • Canada

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04758351 on ClinicalTrials.gov