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Using Exercise-testing to Explore Patient Differences in Severe Asthma

NCT05733143 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 64

Last updated 2025-07-25

No results posted yet for this study

Summary

The goal of this observational pilot study is to use exercise-testing to assess patients with severe asthma who have high levels of breathlessness and compare them to other groups of patients with low levels of breathlessness. We will compare the background and overall fitness levels in all groups. This may provide new knowledge to why these patients remain breathless despite being on treatment with low levels of inflammation.

The main question we aim to answer is:

"How are these patients different compared to patients who respond to treatment?" We will look at reasons why patients with low levels of inflammation in their lungs are still breathless despite being on treatment.

Participants will be required to take part in a 6-month study were they will firstly attend a "study visit" and a 6 month follow up.

At the study visit participants will be consented and required to:

* Complete questionnaires on their symptoms
* Provide information on their background
* Undergo a physical examination
* Provide blood and urine samples for specific testing for asthma and future investigations
* Perform breathing tests
* Undergo an exercise-test on a treadmill

During this study, researchers will compare this group will to participants who are similar but whose symptoms respond to treatment. We will also look at other groups of asthma patients who have who have different levels of inflammation in their lungs to see if there are any differences. We predict, these patients will have a different background and features to those whose symptoms respond to treatment.

Conditions

Interventions

OTHER

cardiopulmonary exercise stress test (CPEST)

The study is observational and purely exploratory. We will utilise cardiopulmonary exercise stress testing to assess levels of fitness and causes for symptoms in proposed groups.

Sponsors & Collaborators

  • Belfast Health and Social Care Trust

    collaborator OTHER

  • Queen's University, Belfast

    lead OTHER

Principal Investigators

  • Liam G Heaney, MD · Queens University Belfast

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-18
Primary Completion
2025-11-01
Completion
2025-11-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05733143 on ClinicalTrials.gov