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Effects of Daily Nitrate Consumption on Oral Bacteria Composition, Blood Pressure and Vascular Function

NCT03784742 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 28

Last updated 2024-04-12

No results posted yet for this study

Summary

Diseases of the heart and blood vessels, including raised blood pressure, are one of the leading causes of death worldwide. Higher intakes of dietary nitrate, found abundantly in root vegetables such as beetroot, have been shown to have health benefits including lowering blood pressure and improving the elasticity of blood vessels. Bacteria which reside in the mouth and those in the gastrointestinal tract play an important role in converting dietary nitrate to nitrite and nitric oxide (a chemical which promotes the relaxation of blood vessels). In particular, removal of oral bacteria by using antiseptic mouthwash is accompanied by an increase in blood pressure in subjects with normal blood pressure, even after consuming nitrate-rich foods. To date, very little is known about the role of these oral bacteria in the control of blood pressure, and if there are any differences in bacterial composition between individuals.

Conditions

  • No Dental Disease
  • Non-smoking

Interventions

OTHER

Nitrate rich beetroot juice

James White Drinks Limited beetroot juice (0.4-0.45 g nitrate/70 ml drink).

OTHER

Placebo beetroot juice

James White Drinks Limited Placebo beetroot juice (0 nitrate/70 ml drink).

Sponsors & Collaborators

  • Saudi Cultural Bureau

    collaborator UNKNOWN

  • University of Reading

    lead OTHER

Principal Investigators

  • Julie A Lovegrove, BSc, PhD · University of Reading

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-12-01
Primary Completion
2020-12-01
Completion
2021-12-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03784742 on ClinicalTrials.gov