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The Effect of Dietary Nitrate on the Oral Microbiome

NCT03467061 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 101

Last updated 2021-05-27

No results posted yet for this study

Summary

This study evaluates whether dietary manipulation of the oral microbiota modulates cardiovascular health through effects on nitric oxide bioavailability.

Conditions

  • Cardiovascular Health
  • Identify Oral Bacteria Responsible for Nitrate Reduction

Interventions

DIETARY_SUPPLEMENT

Nitrate-rich beetroot juice

concentrated beetroot juice

DIETARY_SUPPLEMENT

Nitrate-depleted beetroot juice

concentrated beetroot juice

OTHER

Mouthwash

2 x 10 mL antibacterial mouthwash per day for 14 days

Sponsors & Collaborators

  • University of Exeter

    lead OTHER

Principal Investigators

  • Andrew M Jones, PhD · University of Exeter

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-10
Primary Completion
2021-05-06
Completion
2021-05-06

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03467061 on ClinicalTrials.gov