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The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function.

NCT06602921 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2025-09-12

No results posted yet for this study

Summary

Dietary inorganic nitrate supplementation may have positive implications on cardiovascular function. The aim of this project is to determine if nitrate supplementation can attenuate the effects that caffeine and cold exposure have on the cardiovascular system.

Conditions

  • Nitrate
  • Caffeine
  • Cold Exposure

Interventions

DIETARY_SUPPLEMENT

TruBeet inorganic beetroot juice

400 mg nitrate-rich beetroot powder, mixed with 300 mL water.

DIETARY_SUPPLEMENT

Caffeine

6 mg/kg caffeine powder in capsule form.

OTHER

Cold pressor test

3 min cold pressor test using the left foot in cold water (0-2 degree).

Sponsors & Collaborators

  • Biogen Extracts Pvt Ltd

    collaborator UNKNOWN

  • Loughborough University

    lead OTHER

Principal Investigators

  • Stephen Bailey · Loughborough University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-12-05
Primary Completion
2024-11-01
Completion
2025-04-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06602921 on ClinicalTrials.gov