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Examination of the Distribution of Nitrate Reducing Bacteria in the Human Oral Cavity

NCT03068962 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2017-03-03

No results posted yet for this study

Summary

Dietary nitrate have been shown to have health benefits including lowering blood pressure (Hobbs et al, 2012), improving endothelial function and inhibiting platelet aggregation in healthy humans (Lidder \& Webb, 2013). The main sources of dietary nitrate in the human diet are vegetables such as beetroot. Nitrates are converted to nitrites then nitric oxide (NO), following their reduction by commensal oral bacteria and those residing in the gastrointestinal tract (Hord, Tang, \& Bryan, 2009; Lidder \& Webb, 2013). A recent study has shown following elimination of oral bacteria by the use of a chlorhexidine based antiseptic mouthwash, the conversion of nitrate to nitrite is prevented and this is accompanied by a statistically significant increase in blood pressure in normotensive subjects (Kapil et al., 2013). To date, very few studies have investigated the potential role of these oral bacteria in control of blood pressure and if there are any inter and intra-individual differences in bacterial composition.

Conditions

  • No Dental Disease
  • Non-smoking

Interventions

OTHER

beetroot Juice

Beetroot Juice

OTHER

Buxton water

natural mineral water

OTHER

antiseptic mouthwash then beetroot juice

Chlorhexidine glocunate

Sponsors & Collaborators

  • University of Reading

    lead OTHER

Principal Investigators

  • Julie A Lovegrove, BSc, PhD · University of Reading

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-03-31
Primary Completion
2017-09-30
Completion
2018-03-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03068962 on ClinicalTrials.gov