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Effects of Dark Chocolate on Exercise Capacity, and Mitochondrial Structure and Function

NCT01671514 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 21

Last updated 2015-06-03

No results posted yet for this study

Summary

The major goal of this study is to characterize the ability of dark chocolate enriched in epicatechin (a component of dark chocolate) to improve the structural and functional features of mitochondria in two groups

1. Patients with heart failure (HF) and type 2 diabetes (DM2) and
2. Normal yet sedentary individuals with impaired baseline exercise capacity (as assessed by VO2 max)

We propose that a 3 month treatment with dark chocolate will lead to a significant improvement in exercise capacity which will be secondary to the improvement in skeletal muscle structure from epicatechin.

Conditions

Interventions

DIETARY_SUPPLEMENT

Epicatechin-enriched dark chocolate

For experimental purposes, subjects will take one square of epicatechin-enriched dark chocolate per day for 90 days.

OTHER

Low-epicatechin dark chocolate

As a placebo control, subjects will take 1 square of low-epicatechin chocolate per day for 90 days.

Sponsors & Collaborators

Principal Investigators

  • Pam Taub, MD · Assistant Professor of Medicine, University of California, San Diego

Study Design

Allocation
RANDOMIZED
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-07-31
Primary Completion
2014-12-31
Completion
2014-12-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01671514 on ClinicalTrials.gov