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Effect of Ketogenic Diet on Glucose Metabolism and Energy Expenditure in Type 2 Diabetes

NCT04791787 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2024-06-11

No results posted yet for this study

Summary

The study team will examine the effect of a ketogenic diet alone and ketogenic diet supplemented with oral ketones on how the body of individuals with type 2 diabetes respond to insulin, regulates insulin secretion, food intake and energetic pathways and influences body fat distribution.

Conditions

  • Glucose Metabolism Disorders (Including Diabetes Mellitus)
  • Energy Supply; Deficiency
  • Type 2 Diabetes

Interventions

OTHER

Standard weight maintaining diet

Diet containing diet approximately 25-35% protein, 45-55% carbohydrate, 20- 30% fat

OTHER

Weight maintaining isocaloric ketogenic diet

Isocaloric ketogenic diet containing approximately 15-25% protein, 5-10% carbohydrate,70- 80% fat

DIETARY_SUPPLEMENT

Beta-hydroxy butyrate

A supplement of ketone ester of beta-hydroxy butyrate

Sponsors & Collaborators

  • The University of Texas Health Science Center at San Antonio

    lead OTHER

Principal Investigators

  • Ralph DeFronzo, MD · University of Texas Health at San Antonio

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-11-25
Primary Completion
2023-04-25
Completion
2023-04-25

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04791787 on ClinicalTrials.gov