Acceptance and Commitment Therapy for Muscle Disease

Summary

In adults, muscle diseases are usually chronic long-term conditions that do not have a definitive cure. Supportive care has been shown to reduce complications from muscle disease and improved survival in some cases. However, there has been limited research to evaluate interventions that may improve quality of life (QoL) with this patient group. The QoL of those with MD is not just affected by the severity of their MD but also a variety of psychological variables. Based upon the knowledge of these psychological variables the investigators feel that a particular type of psychological intervention known as "acceptance and commitment therapy" (ACT) could potentially improve QoL in those with MD. The investigators therefore propose to test whether ACT does in fact improve QoL in those with MD by randomising 154 patients to receive either standard medical care plus a guided self-help ACT programme, or standard medical care only.

Conditions

• Muscle Diseases

Interventions

BEHAVIORAL

Acceptance and Commitment Therapy (ACT)

Acceptance and Commitment Therapy (ACT) is a form of cognitive behavioural therapy focused explicitly on promoting psychological flexibility. An ACT programme suits the aims of the study because it targets avoidance of distress, promotes acceptance of illness through motivating meaningful activity outside of illness, improves the processes that underlie beliefs rather than by directly challenging beliefs, thus reducing possible trivialisation of the understandable distress caused by living with MD.

Sponsors & Collaborators

• King's College London

  collaborator OTHER

• Barts & The London NHS Trust

  collaborator OTHER

• Muscular Dystrophy Association

  collaborator OTHER

• University Hospital Southampton NHS Foundation Trust

  collaborator OTHER

• King's College Hospital NHS Trust

  lead OTHER

Principal Investigators

• Michael Rose · King's College Hospital NHS Trust

• Trudie Chalder · King's College London

• Lance McCracken · King's College London

• Christopher Graham · University of Leeds

• Sam Norton · King's College London

• Aleksandar Radunovic · Barts & The London NHS Trust

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-07-31

Primary Completion

2018-04-30

Completion

2019-01-31

Countries

• United Kingdom

Study Locations