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Genetic Basis for Prediction of Non-responders to Dietary Plant Sterol Intervention

NCT02765516 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 43

Last updated 2020-06-01

No results posted yet for this study

Summary

The objective of this study is to utilize information on associations between genetic predisposition pertaining to multiple single nucleotide polymorphisms (SNPs) and the degree of responsiveness of low-density lipoprotein cholesterol (LDL-C) lowering to plant sterols (PS). The predictive potential of SNPs associated with PS responsiveness will be evaluated using a randomized human intervention trial examining responsiveness of lowering blood LDL-C levels to PS intervention.

Conditions

Interventions

OTHER

Plant sterols

2.0g/day of plant sterols incorporated into margarine to be consumed for 28 days

OTHER

Placebo

Identical margarine without additional plant sterols to be consumed for 28 days

Sponsors & Collaborators

  • Mitacs

    collaborator INDUSTRY

  • Unilever R&D

    collaborator INDUSTRY

  • Nutritional Fundamentals for Health

    collaborator UNKNOWN

  • University of Manitoba

    lead OTHER

Principal Investigators

  • James House, PhD · University of Manitoba

  • Dylan Mackay, PhD · University of Manitoba

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-07-05
Primary Completion
2019-12-31
Completion
2019-12-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02765516 on ClinicalTrials.gov