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Dietary Salt and Microvascular Function

NCT02727426 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2016-04-05

No results posted yet for this study

Summary

It is well accepted that high-salt (HS) intake is an essential risk factor in development and progression of hypertension. Results of some recent studies suggest that some of the deleterious effects of a HS diet are independent of elevated blood pressure (BP) and may occur in normotensive individuals and are associated with impaired endothelial function. However, the effects of acute salt loading on endothelial function and vascular reactivity in young healthy individuals are still scarce and inconsistent.

The purpose of present study is to determine whether one week of HS intake affects microvascular reactivity in young healthy subjects without changes in BP. In addition, the investigators sought to evaluate if potential HS diet-induced microvascular dysfunction is associated with changes in oxidative stress level and/or with modification of immunological response in young healthy subjects.

Conditions

  • Salt; Excess

Interventions

OTHER

Low Salt (LS) diet

Intake of less than 2.3 g of salt per day for 7 days.

OTHER

High Salt (HS) diet

Intake of 11.2 g of salt per day for 7 days.

Sponsors & Collaborators

  • Josip Juraj Strossmayer University of Osijek

    lead OTHER

Principal Investigators

  • Ines Drenjancevic, MD, PhD · Faculty of Medicine, University of Osijek, Croatia

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-02-29
Primary Completion
2017-05-31
Completion
2017-12-31

Countries

  • Croatia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02727426 on ClinicalTrials.gov