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Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity

NCT02490527 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2021-09-29

No results posted yet for this study

Summary

The purpose of this study is to gain insight into the side-effects of statin consumption, and assess the ability of epicatechin (a compound in dark chocolate) to counteract or reverse these changes. The investigators' prior research has shown that epicatechin can improve skeletal muscle structure and mitochondrial (which gives us energy) structure.

Conditions

  • Statin Intolerance

Interventions

DIETARY_SUPPLEMENT

Pure epicatechin capsules (50mg)

Epicatechin is a compound found naturally in dark chocolate.

DRUG

Simvastatin (40mg)

A cholesterol-lowering medication that blocks the production of cholesterol.

OTHER

Placebo

A substance that has no therapeutic effect and will act as a control.

Sponsors & Collaborators

Principal Investigators

  • Pam Taub, M.D. · University of California, San Diego

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2021-07-28
Completion
2021-07-28

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02490527 on ClinicalTrials.gov