Also known as: UC San Diego, University of California San Diego
A first-in-human T-cell therapy showed lasting benefit in children with DIPG and relapsed CNS tumors, while a preclinical mRNA vaccine reduced neuroblastoma tumor size by 70%. Aneuploidy predicted response to olaparib plus irinotecan.
Researchers have developed an integrated live-cell imaging and cytometry workflow to monitor brain organoid differentiation. Separately, experiments on the International Space Station show that microgravity accelerates organoid aging by roughly a decade in 30 days, offering a faster model for neurodegenerative diseases. These advances could enhance drug discovery and neurodevelopmental research.
A prototype smart ring tracks multiple metabolic biomarkers in sweat, while Amazon One Medical launches Health Insights for blood biomarker analysis. Pharmacies are also using point-of-care testing to personalize supplement recommendations.
UC San Diego is using space-based research to fight cancer and Alzheimer's, including the longest-running biologic experiments in space. A 2024 World Economic Forum report forecasts the space economy reaching $1.8 trillion by 2035.
Two studies identify protein recycling dysfunction and transcription factors ZSCAN20/JDP2 as drivers of T-cell exhaustion, with E3 ligases and gene deactivation offering reversal pathways. A third study finds TCF1 insufficient to revert terminally exhausted T cells.
Researchers identify DPY30 as an epigenetic target to sensitize pancreatic tumors to immunotherapy. UC San Diego researchers redirect CMV immunity against pancreatic cancer in preclinical models. A Fred Hutch researcher receives ACS grant to study immunotherapy resistance in melanoma.
NIH has obligated only 15% of its $38 billion budget halfway through the fiscal year, causing universities to cut PhD admissions and implement hiring freezes. Early-career scientists face declining grant success rates despite increased applications. Congress recently reversed proposed 40% NIH budget cuts that had threatened research facility construction.
Researchers have developed advanced platforms to study human neural networks, including 3D bioelectronics for brain organoids and scalable 2D neuron networks that reveal brain-like rhythms and drug responses.
Scientists have developed multiple breakthrough delivery systems for gene editing and mRNA therapies, including a simple amino acid supplement that increases delivery 20-fold and a CRISPR gene drive that reverses antibiotic resistance in bacterial populations.
Scientists at UC San Diego have identified N4BP2 as the enzyme responsible for chromothripsis, a chaotic chromosome-shattering event seen in about one in four cancers that enables rapid tumor evolution and treatment resistance.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07761143 |
Impact of Device Free Summer Camp on Adolescent Mental Health and Wellbeing |
COMPLETED | NA |
| NCT07756567 |
Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for Psychosis |
NOT_YET_RECRUITING | NA |
| NCT07756528 |
Stakeholder-Informed RSV Prevention Economic Model in Botswana |
ACTIVE_NOT_RECRUITING | |
| NCT07749391 |
Developing and Testing a Brief, Personalized Intervention for Suicidal Thoughts and Behaviors |
ACTIVE_NOT_RECRUITING | NA |
| NCT07745101 |
Research On Advanced Diagnostics and Management of All Pregnancies to Prevent Stillbirth (ROADMAPS) |
NOT_YET_RECRUITING | |
| NCT07729046 |
Neu Direction: Testing the Efficacy of Adding HER Inhibition to Standard of Care in Metastatic MLH1-low Endocrine-resistant ER+/HER2- Breast Cancer |
NOT_YET_RECRUITING | PHASE2 |
| NCT07725250 |
Behavioral Interventions Combining AI/ML and Personalized Medicine to Reduce Cardiovascular Risk - Randomized Controlled Trial |
RECRUITING | NA |
| NCT07713940 |
Effect of Anti-inflammatory Diet in Systemic Lupus Erythematous |
RECRUITING | NA |
| NCT07706595 |
A Randomized Controlled Trial Comparing Posterior Nasal Nerve Ablation Procedures for Chronic Rhinitis |
ENROLLING_BY_INVITATION | NA |
| NCT07693543 |
Nicotinamide Riboside Supplementation in Chronic Kidney Disease |
NOT_YET_RECRUITING | PHASE2 |
