Also known as: University of California San Diego
Two studies identify protein recycling dysfunction and transcription factors ZSCAN20/JDP2 as drivers of T-cell exhaustion, with E3 ligases and gene deactivation offering reversal pathways. A third study finds TCF1 insufficient to revert terminally exhausted T cells.
Researchers identify DPY30 as an epigenetic target to sensitize pancreatic tumors to immunotherapy. UC San Diego researchers redirect CMV immunity against pancreatic cancer in preclinical models. A Fred Hutch researcher receives ACS grant to study immunotherapy resistance in melanoma.
NIH has obligated only 15% of its $38 billion budget halfway through the fiscal year, causing universities to cut PhD admissions and implement hiring freezes. Early-career scientists face declining grant success rates despite increased applications. Congress recently reversed proposed 40% NIH budget cuts that had threatened research facility construction.
Researchers have developed advanced platforms to study human neural networks, including 3D bioelectronics for brain organoids and scalable 2D neuron networks that reveal brain-like rhythms and drug responses.
Scientists have developed multiple breakthrough delivery systems for gene editing and mRNA therapies, including a simple amino acid supplement that increases delivery 20-fold and a CRISPR gene drive that reverses antibiotic resistance in bacterial populations.
Scientists at UC San Diego have identified N4BP2 as the enzyme responsible for chromothripsis, a chaotic chromosome-shattering event seen in about one in four cancers that enables rapid tumor evolution and treatment resistance.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07592169 |
Confirmatory Trial of Gamma Neurofeedback to Improve Working Memory in Schizophrenia |
NOT_YET_RECRUITING | PHASE2 |
| NCT07582484 |
Gene Therapy Trial for CLN6 Batten Disease |
NOT_YET_RECRUITING | PHASE1/PHASE2 |
| NCT07581340 |
Using AI to Improve Sepsis Quality of Care in the Emergency Department |
COMPLETED | NA |
| NCT07579364 |
Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery |
ENROLLING_BY_INVITATION | |
| NCT07576842 |
Testing the Feasibility of Different HPV Screening and Care Strategies for Women Living With HIV |
NOT_YET_RECRUITING | NA |
| NCT07541131 |
Lower Intersecting HIV-related Stigmas to Facilitate Treatment as Prevention (LIFT) |
ENROLLING_BY_INVITATION | NA |
| NCT07527364 |
Evaluation of Changing the Scripts Intervention in Nigeria |
RECRUITING | NA |
| NCT07524751 |
Culturally Adapted Pain Management for Indigenous Peoples |
NOT_YET_RECRUITING | NA |
| NCT07518784 |
Accurate Point of Care Liver Disease Diagnostics (Phase 2) |
RECRUITING | |
| NCT07512284 |
Mindfulness Engaged Neurostimulation for Depression (MEND II) |
RECRUITING | PHASE2 |
