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Alternative Antibiotic Regime in the Treatment of GAgP

NCT02223702 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 39

Last updated 2018-11-02

Study results available
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Summary

The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin plus metronidazole combined with non-surgical treatment in patients with generalized aggressive periodontitis (GAgP) in 6-month follow-up.

A total of 40 systemically healthy patients with GAgP will evaluate in this randomized clinical trial. Periodontal parameters (plaque index, gingival index, probing depth, bleeding on probing, clinical attachment level) will be recorded at baseline, 1st, 3rd and 6th month. Patients will receive either 400 mg moxifloxacin per os once daily or 500 mg metronidazole and 500 mg amoxicillin per os three times daily for 7 days consecutively.

Conditions

  • Generalized Aggressive Periodontitis
  • Aggressive Periodontitis

Interventions

DRUG

Amoxicillin

500 mg, 3 times per day for 7 days

DRUG

Metronidazole

500 mg, 3 times per day, for 7 days

DRUG

Moxifloxacin

400 mg, once in a day for 7 days.

Sponsors & Collaborators

  • Kocaeli University

    lead OTHER

Principal Investigators

  • Esra Guzeldemir-Akcakanat · Kocaeli University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-05-31
Primary Completion
2012-05-31
Completion
2014-07-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02223702 on ClinicalTrials.gov