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Bacteria in Dental Plaque and Atheroma Plaque

NCT07100574 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2025-08-03

No results posted yet for this study

Summary

Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood. Periodontal pathogen components such as DNA, RNA or specific antigens of P. gingivalis, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Fusobacterium nucleatum (F. nucleatum) or Campylobacter rectus have been isolated from different tissues such as atheroma plaques, placenta, amniotic sac and respiratory tract. It has been reported that periodontitis may contribute to endothelial dysfunction leading to the formation of atherosclerosis.

Conditions

  • Gingival Inflammation
  • Dental Plaque
  • Atheroma Plaque
  • Oral Bacteria

Interventions

OTHER

atheroma plaque

During the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.

OTHER

dental plaque

Subgingival plaque samples will be collected from patients before the endarterectomy procedure.

Sponsors & Collaborators

  • Istanbul Saglik Bilimleri University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-10
Primary Completion
2025-12-30
Completion
2026-03-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07100574 on ClinicalTrials.gov