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Amoxicillin and Metronidazole During or After the Periodontal Treatment

NCT06177119 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 72

Last updated 2023-12-20

No results posted yet for this study

Summary

This randomized clinical trial aimed to compare the clinical and microbiological effects of different times of administration of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of periodontitis.

Conditions

  • Periodontitis

Interventions

PROCEDURE

Scaling and root planing

SRP will be performed in four to six appointments lasting approximately 1 h each, using manual curettes (Hu-Friedy, Chicago, IL, USA) and ultrasonic device (Cavitron Select SPC, Dentsply professional, York, PA, USA) under local anesthesia. The deep sites will be scaled throughout the first week and treatment of the entire oral cavity will be completed in 14 days.

DRUG

Placebos during SRP

Amoxicillin and metronidazole placebos thrice a day for 14 days, beginning with the first SRP session.

DRUG

Placebos after SRP

Amoxicillin and metronidazole placebos thrice a day for 14 days, beginning after the last SRP session.

DRUG

Metronidazole during SRP

Metronidazole 400 mg, thrice a day for 14 days, beginning with the first SRP session.

DRUG

Amoxicillin during SRP

Amoxicillin 500 mg, thrice a day for 14 days, beginning with the first SRP session.

DRUG

Metronidazole after SRP

Metronidazole 400 mg, thrice a day for 14 days, beginning after the last SRP session.

DRUG

Amoxicillin after SRP

Amoxicillin 500 mg, thrice a day for 14 days, beginning after the last SRP session.

Sponsors & Collaborators

  • Belén Retamal-Valdes

    lead OTHER

Principal Investigators

  • Marcelo Faveri, Professor · University of Guarulhos

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-01-31
Primary Completion
2012-07-01
Completion
2024-12-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06177119 on ClinicalTrials.gov