MedTrace Logo

Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy

NCT05608564 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 38

Last updated 2025-07-17

Study results available
· View outcomes & findings →

Summary

The main treatment of every patient with periodontitis is non-surgical periodontal treatment (NSPT) with the ultimate goal to arrest inflammation. Given the biofilm microorganisms associated etiology of the periodontitis, NSPT can be combined with adjunctive antimicrobial therapy. Hence, this randomized clinical trial aims to compare the clinical and microbiological effectiveness and relative expression levels (REL) of proinflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) between local and systemic antibiotics as adjunctive therapy to NSPT in patents with periodontitis stage 3.

Conditions

  • Periodontitis

Interventions

PROCEDURE

Piperacillin and Tazobactam in gel form

After non-surgical periodontal treatment, the test group will receive local antibiotics.

PROCEDURE

Amoxicillin and Metronidazole

After non-surgical periodontal treatment, the control group will receive systemic antibiotics.

Sponsors & Collaborators

  • University of Belgrade

    lead OTHER

Principal Investigators

  • Iva Z Milinkovic, DDS, PhD · School of Dental Medicine, University of Belgrade, Department of Periodontology and Oral Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-17
Primary Completion
2023-08-10
Completion
2024-03-11

Countries

  • Serbia

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05608564 on ClinicalTrials.gov