Control of Periodontal Infections

Summary

The purpose of this study is to test combined effects of scaling and root planing with periodontal surgery, systemically administered amoxicillin and metronidazole, and/or local tetracycline on pocket depth reduction and attachment level "gain" in patients with chronic periodontitis.

Conditions

• Periodontitis

Interventions

OTHER

scaling and root planing

scaling and root planing as a single therapy

DRUG

local tetracycline

local delivery of tetracycline fibers releasing approximately 1.7 mg/tooth in all pockets \>5mm

DRUG

systemic metronidazole and amoxicillin

systemic metronidazole (250 mg tid x 14) and amoxicillin (500 mg bid x 14

OTHER

surgery

periodontal surgery in residual pockets of \>4mm

DRUG

local antibiotics and systemic metronidazole and amoxicillin

1.7 mg/tooth tetracycline fiber plus metronidazole (250 mg tid x14d)and amoxicillin (500 mg bid x 14d)

OTHER

local tetracycline and periodontal surgery

local delivery of tetracycline fibers releasing approximately 1.7 mg/tooth in all pockets \>5mm and periodontal surgery in residual pockets of \>4mm

OTHER

periodontal surgery and systemic metronidazole and amoxicillin

surgery in residual pockets \>4mm and metronidazole (250mg tidx14d) and amoxicillin (500mg bidx14d)

OTHER

surgery, local tetracycline, systemic metronidazole and amoxicillin

periodontal surgery in residual pockets \>4mm, tetracycline ibers releasing approximately 1.7 mg/tooth in pockets \>5mm, systemic metronidazlo (250mg tidx14d) and amoxicillin (500 mg bidx14d)

Sponsors & Collaborators

• Göteborg University

  collaborator OTHER

• Boston University

  collaborator OTHER

• The Forsyth Institute

  lead OTHER

Principal Investigators

• J Max Goodson, DDS, PhD · The Forsyth Institute

• Anne D Haffajee, BDS · The Forsyth Institute

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

FACTORIAL

Eligibility

Min Age

20 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1999-09-30

Primary Completion

2004-12-31

Completion

2004-12-31

Countries

• United States

Study Locations