MedTrace Logo

Effect of Apples on cardioVascular Risk And Gut Health

NCT01988389 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2015-03-09

No results posted yet for this study

Summary

There is now considerable scientific evidence that a diet rich in fruits and vegetables could improve human health. Apples are among the most frequently consumed fruits in the world. Epidemiological studies have linked frequent apple consumption with several health benefits including a reduced risk of cardiovascular disease. Apples are an important source of polyphenols and fiber and their beneficial effects could be attributed to this content; however, their impact on our health is not clear. Although, there are some studies that have reported cholesterol lowering effects the results are inconsistent. Furthermore, few studies have explored the impact on vascular function and gut microbiota. The objective of the current study is to assess whether a regular apple consumption, reduces total cholesterol levels, improves vascular function and gut microbiota profile in mildly hypercholesterolemic subjects compared with a control, sugar matched commercial clear apple juice squash.

Conditions

  • Mild Hypercholesterolemia

Interventions

DIETARY_SUPPLEMENT

whole apples (WA)

DIETARY_SUPPLEMENT

apple juice (AJ)

Sponsors & Collaborators

  • Fondazione Edmund Mach di San Michele all'Adige

    collaborator OTHER

  • University of Reading

    lead OTHER

Principal Investigators

  • Julie A Lovegrove, BSc, PhD, RNutr · University of Reading

  • Kieran Tuohy, Dr · FEM-IASMA Research and Innovation centre

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
23 Years
Max Age
69 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-09-30
Primary Completion
2014-10-31
Completion
2014-11-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01988389 on ClinicalTrials.gov