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Effects of Tart Cherry and Aroniaberry Supplementation on Endothelial Function and Cardiovascular Measures in Healthy Older Adults: Interactions With Genotype and Proteome

NCT02379403 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2017-10-06

No results posted yet for this study

Summary

Background:

\- Heart disease is the leading cause of death and disabilities in the United States. Diets high in fruits and vegetables may reduce the risk of heart disease. Fruits, including red tart cherries and purple aroniaberries, may be especially beneficial. Researchers want to know how tart cherry and aroniaberry extracts affect heart health.

Objective:

\- To study the benefits of tart cherry and aroniaberry extract on vascular function and other measures. These include inflammation, oxidation, and cholesterol.

Eligibility:

\- Men and post-menopausal women ages 55 70 in good health and with normal or slightly high blood pressure or cholesterol.

Design:

* Participants will be screened with a physical exam, medical history, and blood tests.
* Participants will have 6 visits. They will have blood taken at every visit.
* Visit 1:
* Blood vessel tests. Participants will lie down. Heart rhythm will be monitored. A device will be placed on the upper arm, and pictures of blood vessels will be taken.
* A blood pressure cuff will be tightened around the lower arm for 5 minutes.
* Cardio-Ankle-Vascular Index (CAVI). Blood pressure cuffs will be placed on both arms and legs. They will be tightened with air at the same time for a few minutes.
* Participants will be assigned to one of three groups. For 3 weeks each, in random order, they will take: aroniaberry capsules, tart cherry capsules, placebo capsules, and no capsules.
* Participants will answer questions online about their eating and exercise.
* Participants will be keep a record of what they eat for a few periods. They will come for a study visit every 3 weeks through week 15.

Conditions

Sponsors & Collaborators

  • National Institute of Nursing Research (NINR)

    lead NIH

Principal Investigators

  • Mary B Engler, Ph.D. · National Institute of Nursing Research (NINR)

Eligibility

Min Age
55 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-02-19
Primary Completion
2017-05-09
Completion
2017-05-09

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02379403 on ClinicalTrials.gov