MedTrace Logo

Prediction of Propofol Effect-Site Concentration Associated With Deep Anesthesia

NCT06346158 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2026-01-16

No results posted yet for this study

Summary

The goal of this observational study is to explore the variability of the concentration at the effect site (Ce) of propofol to reach deep anesthesia (DA) during induction of general anesthesia in adults.

The investigators hypothesized that there is a great variability in this Ce that could be precisely explained by

* Electroencephalographic (EEG) features available prior to induction of anesthesia
* Cognitive performance
* Patients characteristics Participants will undergo preoperative cognitive testing and awake EEG. Then, induction of general anesthesia will be performed using continuous infusion of propofol. The Ce at which Deep anesthesia is observed will be recorded.

Conditions

  • Anesthesia

Interventions

DIAGNOSTIC_TEST

Cognitive testing

Preoperative cognitive battery test

DEVICE

electroencephalogram

Preoperative 24 channel EEG

DEVICE

High density electroencephalogram

preoperative 128-channel electroencephalogram

PROCEDURE

General anesthesia

induction of general anesthesia using propofol 1%

Sponsors & Collaborators

  • Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal

    collaborator OTHER

  • Ciusss de L'Est de l'Île de Montréal

    lead OTHER

Principal Investigators

  • Louis Morisson, MD, MSc · CIUSSS de l'Est de l'Ile de Montréal

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-07
Primary Completion
2027-01-31
Completion
2027-01-31
FDA Device
Yes

Countries

  • Canada

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06346158 on ClinicalTrials.gov