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Melanocortin 4 Receptor Mutations and Obesity-associated Diseases

NCT01849705 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 226

Last updated 2013-05-08

No results posted yet for this study

Summary

Mutations in the melanocortin 4 receptor (MC4R) are the most common form of monogenic obesity, and can explain 2-6% of severe obesity.

Studies have shown that mutations in MC4R are associated with increased fat mass, height-for-age, appetite and insulin resistance among children. In adults, mutations in MC4R are less penetrant for these phenotypes but it has been observed that individuals with MC4R mutations have a smaller than expected blood pressure for their degree of obesity.

The purpose of this study is to explore the association between functional MC4R mutations and obesity, insulin resistance and blood pressure.

Conditions

Interventions

OTHER

No intervention

Sponsors & Collaborators

  • Rhythm Pharmaceuticals, Inc.

    collaborator INDUSTRY

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Arne Astrup, MD, Dr. Med · Department of Human Nutrition, University of Copenhagen

  • Lesli H Larsen, PhD · Department of Human Nutrition, University of Copenhagen

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-10-31
Primary Completion
2013-02-28
Completion
2013-02-28

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01849705 on ClinicalTrials.gov