Brain and Behavior Influences on Obesity Development From Infancy Through Childhood

Summary

The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of families of children from infancy through childhood. The results will lay foundations for the development of early interventions to prevent or treat obesity.

Conditions

• Obesity and Overweight

Interventions

OTHER

fMRI cue reactivity task

Measures effect of food and non-food cues on brain activation

OTHER

fMRI go no go task

Measures effect of food and non-food cues on inhibitory responses and brain activation

OTHER

Ad libitum meal test

Measures effect of exposure to multi-item buffet meal on food intake

OTHER

Eating in the absence of hunger test

Measures effect of exposure to palatable snacks on food intake

Sponsors & Collaborators

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  collaborator NIH

• Rhode Island Hospital

  collaborator OTHER

• Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

  collaborator OTHER

• University of Washington

  collaborator OTHER

• Johns Hopkins University

  lead OTHER

Principal Investigators

• Susan Carnell, PhD · Johns Hopkins University

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

7 Years

Max Age

12 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-12-02

Primary Completion

2029-03-31

Completion

2029-03-31

Countries

• United States

Study Locations