Metabolic Syndrome and Gen-polymorphs Influence on Weightloss Among Children in Treatment for Overweight

Summary

Definition:

the overall objective is to examine childhood obesity with focus on NAFLD and its treatment. Further, we aimed to investigate the impact of genetic variation on obesity.

The specific aims are to;

* describe the degree of NAFLD among overweight and obese, Danish children. (hypothesis; the degree for pediatric NAFLD among Danish Children was equal that found in other Caucasian paediatric study populations).
* investigate the effect of a multidisciplinary intervention treatment of 1 year on liver fat content.

(hypothesis; the intervention could reduce the liver fat percentage and a reduction in BMI SDS would associate with a reduction in liver fat content) - Analyze changes in liver fat content in relation to changes in levels of fasting blood variables to see if any of them could be used as a clinical tool for monitoring hepatic steatosis in the clinic.

(hypothesis; serum aminotransferases (separately and their ratio, respectively), serum insulin, and HOMA-IR could predict improvement in liver fat content

\- Investigate the association between genetic variants and obesity.

Conditions

• Childhood Obesity
• NAFLD (Non-alcoholic Fatty Liver Disease)
• Hypertension
• Hyperlipidemia
• Insulin Sensitivity

Interventions

OTHER

Chronic care multidisciplinary intervention of childhood obesity

Overweight and obese Children, 5-20 Years old, followed by Paediatricians and other Health Personals (multidisciplinary team). Included at their first visit in the clinic (baseline)and follow-up after \~ 1 Year.

Sponsors & Collaborators

• University of Copenhagen

  collaborator OTHER

• Hagedorn Research Institute

  collaborator OTHER

• The Novo Nordisk Foundation Center for Basic Metabolic Research

  collaborator OTHER

• Herlev Hospital

  collaborator OTHER

• Holbaek Sygehus

  lead OTHER

Principal Investigators

• Dorthe S. Bille, MD · Paediatric department, University Hospital Holbaek, Region Zealand, University of Copenhagen, Denmark

Eligibility

Min Age

5 Years

Max Age

20 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2009-01-31

Primary Completion

2012-08-31

Completion

2012-08-31

Countries

• Denmark

Study Locations