MedTrace Logo

Healthy vs Unhealthy Obesity: Mehanistic Insights and Effects of Time-Restricted Eating

NCT05136313 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 53

Last updated 2024-10-01

No results posted yet for this study

Summary

Obesity-related cardiometabolic diseases are now a leading cause of death worldwide. These diseases result from a dysfunctional adipose tissue (AT) that induces inflammation, insulin resistance and altered endocrine function. However, not all obese people develop metabolic complications, which has given rise to the concept of "metabolically healthy obesity" (MHO). Recent evidence suggests that intermittent fasting methods, in particular time-restricted eating (TRE) may be effective in improving cardiometabolic health, independently of weight loss, and this could be particularly effective in MUO subjects. The investigators hypothesize that in young male adults TRE is a more effective/beneficial approach in MUO than in MHO due to the weight loss-independent improvement in their inflammatory and metabolic derangements. To this aim, a 16-week 8h TRE intervention study will be performed in MHO and MUO subjects, assessing anthropometric, endocrine, and other outcomes.

Conditions

  • Metabolically Healthy Obesity
  • Intermittent Fasting

Interventions

BEHAVIORAL

Time-restricted eating

16 weeks of TRE consisting of an 8-hour eating window.

Sponsors & Collaborators

  • Agencia Nacional de Investigación y Desarrollo

    collaborator OTHER

  • Universidad Católica del Maule

    collaborator OTHER

  • Instituto de Nutrición y Tecnología de los Alimentos

    lead OTHER

Principal Investigators

  • Mariana Cifuentes, PhD · Universidad de Chile INTA

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-24
Primary Completion
2024-01-04
Completion
2024-01-04

Countries

  • Chile

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05136313 on ClinicalTrials.gov