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Human Mitochondrial Stress-driven Obesity Resistance

NCT06080568 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2025-06-22

No results posted yet for this study

Summary

The overarching aim of this observational study is to determine alterations in energy balance while exploring the underlying cellular mechanisms in human genetic models of mitochondrial stress.

In a case-control design, individuals with pathogenic mitochondrial DNA mutations will be compared to healthy controls matched for sex, age, and physical activity level. Participants will attend a screening visit and an experimental trial including assessments of energy expenditure, appetite sensation, energy intake, and muscle and subcutaneous adipose tissue biopsy samples.

Conditions

  • Mitochondrial Diseases
  • Mitochondrial Myopathies
  • Mitochondrial Disorder

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Matteo Fiorenza, Ph.D. · Rigshospitalet, Denmark

  • John Vissing, MD · Rigshospitalet, Denmark

  • Signe Torekov, Ph.D. · University of Copenhagen

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-20
Primary Completion
2024-12-20
Completion
2024-12-20

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06080568 on ClinicalTrials.gov